Pregnancy with chronic viral hepatitis B
Conditions
Interventions
TAF antiviral group:TAF
TDF antiviral group:TDF
Sponsors
The Third Affiliated Hospital of Guangzhou Medical University
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.female; 2.Between 20 and 40 years old; 3.HBsAg positive =6 months; 0-24 weeks of pregnancy in accordance with the 2022 China Guidelines for Chronic Hepatitis B antiviral standards Use TAF/TDF antiviral (including but not limited to elevated transaminase, cirrhosis, liver fibrosis, hepatitis B extrahepatic manifestations, etc.); 4.Voluntarily receive TAF/TDF regularly once a day until the end of delivery or long-term use; 5.Good compliance;
Exclusion criteria
Exclusion criteria: 1.Accompanied by viral hepatitis A, C, E or other hepatitis virus infection or AIDS; 2.Accompanied by cirrhosis, liver cancer or other chronic liver disease; 3.Accompanied by heart, lung, kidney and other important organ diseases; 4.Accompanied by autoimmune hepatitis, autoimmune diseases, hypertension, diabetes, thyroid disease; 5.Those with complications from previous pregnancies; 6.Fetal or neonatal growth and development defects in previous pregnancies; 7.Past or current use of nephrotoxic drugs, glucocorticoids, nonsteroidal anti-inflammatory drugs, cytotoxic drugs, or immunomodulators; 8.Ultrasound before medication indicated fetal malformation, fetal development abnormality, placental abnormality, and threatened abortion; 9.Failed to return for regular follow-up visits as planned;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBsAg, HBeAg;HBV-DNA;Deformity rate;Complications of pregnancy;Liver function;HBV-DNA; | — |
Secondary
| Measure | Time frame |
|---|---|
| Growth and development data;Liver function;HBV-DNA; | — |
Countries
China
Contacts
Public ContactXingfei Pan
The Third Affiliated Hospital of Guangzhou Medical University
Outcome results
None listed