Stroke
Conditions
Interventions
Control group:Sham stimulation and conventional rehabilitation therapy
iTBS group:Cerebellar vermis intermittent theta-burst stimulation and conventional rehabilitation therapy
Sponsors
Shanghai Yangzhi rehabilitation hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for stroke in the "Key Points for the Diagnosis of Various Cerebrovascular Diseases" revised by the Fourth National Academic Conference on Cerebrovascular Diseases; 2. Patients with symptomatic unilateral ischemic or hemorrhagic stroke confirmed by brain magnetic resonance imaging or computed tomography for the first time; 3. Lower extremity Brunnstrom stage III.-IV; 4. Age between 18 and 75 years; 5. Patients with stable vital signs and stable condition, subacute stroke patients, with a course of 2 weeks to 6 months; 6. Presence of balance dysfunction with a Berg balance scale score of 20-56; 7. Cognitively functioning, can follow simple verbal commands or instructions, and can cooperate in signing informed consent.
Exclusion criteria
Exclusion criteria: 1. Diagnosed with other neurological diseases; 2. Cerebellar or brainstem damage; 3. Have contraindications involving TMS (e.g., intracranial implants, pacemakers, implanted pumps, and pregnancy); 4. Cognitive impairment is defined as a mini-mental state examination score of <27, severe deficits in communication or execution of commands, and preclusion to cooperation with assessment and treatment; 5. Are taking psychotropic medications; 6. Balance dysfunction before stroke; 7. Have a history of epilepsy; 8. Currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Berg Balance Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Trunk impairment scale;Fugl-Meyer Assessment of Lower Extremity;Timed Up and Go Test;Modified Barthel Index;Equilibrium score;Muscle activation time interval;Acceleration;Functional connectivity;Cortical activation; | — |
Countries
China
Contacts
Public ContactQi Qi
Shanghai Yangzhi rehabilitation hospital
Outcome results
None listed