postoperative delirium
Conditions
Interventions
control group:Inhale normal saline
Sponsors
The Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. 65 years old <= age <= 85 years old. 2. ASA classification grade I - III. 3. Elective total hip replacement or total knee replacement.
Exclusion criteria
Exclusion criteria: 1. Refusal to sign the informed consent form. 2. Suffering from severe central neurological diseases or mental disorders. 3. Taking sedatives or antidepressants. 4. History of drug or alcohol abuse. 5. Cognitive function defects, deafness, dementia, etc. as evaluated by the Mini-Mental State Examination (MMSE), making normal communication impossible. 6. Suffering from asthma or respiratory allergies. 7. Allergic to experimental materials. 8. Recent upper respiratory tract infection with olfactory problems. 9. Severe anemia (hemoglobin <7g/dL) or coagulation disorders. 10. Sick sinus syndrome, severe sinus bradycardia (<45bpm), or second-degree or higher atrioventricular block without a pacemaker. 11. Severe liver disease (Child-Pugh grade C), severe kidney disease (preoperative dialysis)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium within 3 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of delirium;Subtypes of delirium;Duration of delirium;Numerical Rating Scale score;Self Rating Anxiety Scale Score;Richards Campbell Sleep Questionnaire (RCSQ) Score;Postoperative patient controlled analgesia dosage;Duration of hospitalization;The difference in mean arterial pressure before and after intervention;The difference in heart rate before and after intervention;The number of adverse event cases;Neutrophil to Lymphocyte Ratio; | — |
Countries
China
Contacts
Public ContactMaoyin Zhang
The Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed