Gastroesophageal Variceal Bleeding
Conditions
Interventions
Gastroesophageal variceal bleeding group:None
Upper gastrointestinal bleeding group:None
Sponsors
Nanchong Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Gastroesophageal variceal bleeding group: 1.The patients possessed symptoms of gastrointestinal bleeding at the time of admission: vomiting blood and/or black or bloody stools; 2. All patients were diagnosed with upper gastrointestinal bleeding caused by rupture of gastroesophageal varices by endoscopy; 3.Those with complete clinical history data; 4.Voluntarily signed informed consent. Upper gastrointestinal bleeding group: 1. Patients with symptoms of upper gastrointestinal bleeding at the time of admission: vomiting blood and/or black or bloody stools; 2.Those with complete clinical history data;
Exclusion criteria
Exclusion criteria: Gastroesophageal variceal bleeding group: 1. Severe hematologic diseases and severe insufficiency of heart, lungs and other vital organs; 2. Patients with liver cancer or other malignant tumors of systems and tissues; 3. Patients with severe bleeding tendency, severe jaundice, and large amount of ascites; 4. Those with severe systemic infection or treatment with immunological agents; 5. Use of probiotics or antibiotics within 1 month before admission; 6. Pregnant or lactating women; 7. Any situation in which the investigator believes that the participant should be excluded from the study. Upper gastrointestinal bleeding group: 1. Severe hematologic diseases and severe insufficiency of heart, lungs and other vital organs; 2. Patients with gastroesophageal variceal bleeding; 3. Patients with liver cancer or other malignant tumors of systems and tissues; 4. Patients with severe bleeding tendency, severe jaundice, and a large amount of ascites; 5. Those with severe systemic infection or treatment with immunological preparations; 6. Use of probiotics or antibiotics within 1 month before admission; 7. Pregnant or lactating women; 8. Any situation in which the investigator believes that the participant should be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 16S rDNA Analysis of Gut Microbiota;Metagenomic Analysis of Gut Microbiota;Serum Metabolomics Analysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ascites Grading;Gastroscopic;Routine blood test;Blood biochemistry;Rebleeding within six months; | — |
Countries
China
Contacts
Public ContactZhang Tao
Nanchong Central Hospital
Outcome results
None listed