patients undergoing oral cancer microvascular free flap surgery
Conditions
Interventions
Experimental group (early albumin intervention group):Serum albumin was measured every 4 hours from induction of anesthesia until 24 hours after surgery. If the serum albumin concentration decreased b
Control group (conventional treatment group):When plasma albumin levels are not measured during the operation or within 24 hours after surgery, human albumin infusion is not given (unless hemodynamica
Sponsors
Third Hospital of the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) 18-80 years old; 2) Tumor resection and free flap reconstruction for oral and maxillofacial malignancies; 3) Nutritional risk screening (NRS-2002) score =3 points; 4) Preoperative albumin 24h; 6) Obtain informed consent from the patient or family.
Exclusion criteria
Exclusion criteria: 1) Known or suspected allergy to albumin; 2) Pregnant and lactating women; 3) Severe obesity (BMI = 35 kg/m2); 4) Have suffered from severe cardiovascular, respiratory, liver, kidney, blood and immune diseases, which can be defined as: NYHA classification of cardiac function > Class ?; Active myocardial ischemia; Cardiovascular interventions in the past 60 days; Liver cirrhosis; Chronic kidney disease with creatinine clearance < 40ml/min or chronic obstructive disease requiring home oxygen therapy; 5) Patients who have stopped treatment due to poor prognosis; 6) Patients enrolled in other studies within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative complications in patients with at least one clinically relevant Clavien-Dindo classification (CDC) =2 within the first 30 days after surgery;Intraoperative and 24h postoperative fluid volume;Total amount of vasoactive drugs during and after operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of postoperative recovery (QoR15);Flap complication;Wound complication;pulmonary complications;cardiovascular complication;Non-scheduled second surgery after surgery;postoperative delirium;Postoperative hospital stay;Stay at home for 30 days after surgery (DAH30);Re-admission within 30 days after surgery;Death within 30 days; | — |
Countries
China
Contacts
Public ContactHaopeng Zhang
The Third Hospital of the Air Force Medical University
Outcome results
None listed