migraine
Conditions
Interventions
Individualised group:10 TMS sessions in 2 weeks
Sponsors
Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old; male or female; 2. Patients diagnosed with migraine according to the International Classification of Headache Disorders, 3rd Edition (ICHD-III Edition) [1], with first onset before the age of 50 and a history of migraine >1 year; 3. Attacks >=4 days per month in the 3 months before the screening period and during the screening period; 4. Signed informed consent documents, cooperated with the assessment and rTMS treatment, and were aware of any known and potential risks and available alternative treatments.
Exclusion criteria
Exclusion criteria: 1. Patients with TMS contraindications (metal implants, pacemakers, etc.) 2. Severe anxiety and depression due to various reasons (17 HAMD items greater than 35 points, 14 HAMA items greater than 29 points); 3. History of adjustment of migraine preventive medication during the screening period and treatment; 4. Aphasia and cognitive dysfunction (MMSE score <=23); 5. Pregnancy or lactation; 6. Severe comorbidities that cannot be treated as assessed by clinicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| headache days; | — |
Secondary
| Measure | Time frame |
|---|---|
| headache intensity;Pittsburgh Sleep Quality Index (PSQI);Patient Global Impression of Change (PGIC);Functional connectivity; | — |
Countries
China
Contacts
Public ContactXianwei Che
Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed