Breast cancer
Conditions
Interventions
Intervention group:The PCIA regimen for the experimental group consists of dexmedetomidine (2.5 µg/kg) + sufentanil (2 µg/kg) + flurbiprofen axetil (3 mg/kg) + ondansetron 8 mg
The medications for both groups are prepared based on the total body weight of the patients and diluted with normal saline to a total volume of 100 ml. The parameters for the analgesia pump are set as
Control group:The control group’s PCIA regimen consists of sufentanil (2 µg/kg) + flurbiprofen axetil (3 mg/kg) + ondansetron 8 mg. The medications for both groups are prepared based on the total body
Sponsors
China-Japan Union Hospital of Jilin University
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Breast cancer patients scheduled for breast surgery in our hospital’s breast surgery department from December 2024 to April 2025; (2) Preoperative American Society of Anesthesiologists (ASA) physical status classification is between I and II; (3) Age between 18 and 60 years old; (4) Patients have a preoperative AIS score of >=4 points; (5) Complete clinical data; (6) Patients or their family have signed the informed consent for anesthesia and the informed consent for the study.
Exclusion criteria
Exclusion criteria: (1) Allergy to or contraindications for the medication used in this study; (2) Sick sinus syndrome, second-degree or third-degree heart block, or clinically significant sinus bradycardia; (3) Refusal to use patient-controlled intravenous analgesia (PCIA); (4) Long-term use of anticholinergic drugs, benzodiazepine sedatives, tricyclic antidepressants, antipsychotic drugs, antihistamines, H2 receptor antagonists, and opioid analgesics; (5) Preoperative diagnosis of chronic insomnia; (6) Preoperative chemotherapy for malignant tumors; (7) History of breast surgery; (8) BMI greater than 35; (9) Inability to cooperate in completing the scales.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Athens Insomnia Scale;Visual analogue scale;General information; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale;Quality of Recovery-15;Hemodynamic stability; | — |
Countries
China
Contacts
Public ContactZheng Yan
China-Japan Union Hospital of Jilin University
Outcome results
None listed