cardiac disease
Conditions
Interventions
Non delirium group:None
Sponsors
Changhai Hospital, the First Affiliated Hospital of Naval Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Elderly patients >= 60 years old; (2) ASA grades I to IV; (3) Elective cardiac surgery performed with cardiopulmonary bypass under general anesthesia, including coronary artery bypass grafting (CABG), valve surgery, or CABG combined valve surgery; (4) Plan to be admitted to ICU after surgery.
Exclusion criteria
Exclusion criteria: (1) A known history of allergy to the drug under study; (2) Surgery involving the aortic arch; (3) Previous history of cardiac surgery or secondary cardiac surgery; (4) Use deep low temperature to stop circulation; (5) Preoperative left ventricular ejection fraction EF%<30%; (6) Severe liver and kidney function diseases (Child-Pugh grade C, requiring kidney replacement therapy); (7) Severe respiratory diseases; (8) History of neurological or mental illness, or use of antipsychotic drugs; (9) Preoperative Mini-mental State Examination Scale (MMSE) score <= 23; (10) Unable to provide informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The correlation between middle cerebral artery blood flow velocity and mean arterial pressure at different time points during surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of delirium 3 days after surgery;Length of ICU stay; | — |
Countries
China
Contacts
Public ContactWang Jiafeng
Changhai Hospital, the First Affiliated Hospital of Naval Medical University
Outcome results
None listed