obstructive sleep apnea(OSA)
Conditions
Interventions
case group in case-control study:None
control group in case-control study :None
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Age: 18-65 years, regular diet. Patients diagnosed as obstructive sleep apnea disease according to the guidelines were included in the case group, and healthy controls without obstructive sleep apnea and other sleep breathing disorders were included in the control group.
Exclusion criteria
Exclusion criteria: (1) Subjects with trauma, surgery or severe infection within the past year, and with previous history of craniocerebral trauma, neurological, psychiatric or hematological diseases; (2) Subjects with severe hepatic and renal insufficiency; (3) Subjects with malignant tumors, thyroid, adrenal and other systemic diseases; (4) Subjects with the history of autoimmune diseases; (5) Subjects with gastrointestinal diseases affecting intestinal microorganism such as chronic gastritis and gastric ulcer; (6) Subjects who taking antibiotics, traditional Chinese medicine within 1 month or taking probiotics, prebiotics or drinking within 1 week; subjects who suffering colonoscopy or intestinal enema within 1 week. (7)Subjects with previous treatment involved in OSA.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the level of metabolites;composition of gut microbiota;the gene expression of gut microbiota; | — |
Countries
China
Contacts
Public ContactChen Xiong
Zhongnan Hospital of Wuhan University
Outcome results
None listed