Gastrointestinal disease
Conditions
Interventions
Group A: Nalbuphine hydrochloride combined with propofol:Nalbuphine hydrochloride combined with propofol
Group B: Sufentanil in combination with propofol:Sufentanil in combination with propofol
Sponsors
Affiliated Hospital of Guangdong Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age between 18 to 75, gender limitation; 2.Meet the indications for painless colonoscopy, such as requiring gastroenteroscopy for the diagnosis or treatment of gastrointestinal diseases; 3.No history of related drug allergy, especially to nalbuphine hydrochloride and propofol; 4.No serious cardiopulmonary diseases, such as heart failure, serious arrhythmia, serious respiratory diseases, etc; 5.Liver and kidney function was basically normal, with no history of severe liver and kidney insufficiency; 6.Able to understand and cooperate with the study requirements, and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. History of severe cardiopulmonary diseases, such as heart failure, severe arrhythmia, severe respiratory diseases, etc.; 2. Liver and kidney insufficiency, with a history of severe liver and kidney dysfunction; 3. History of mental illness, such as epilepsy, schizophrenia, etc.; 4. Pregnant or lactating women; 5. Recent use of drugs that may affect the results of the study, such as analgesics, sedatives, antidepressants, etc.; 6. Unable to understand and cooperate with the research requirements, such as language communication disorders, cognitive impairments, etc.; 7. Those who participated in any clinical trial as a subject within 3 months prior to enrollment; 8. Other circumstances judged by the investigator to be unsuitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analgesia effect (use discomfort score); | — |
Secondary
| Measure | Time frame |
|---|---|
| depth of sedation (MOAA / S score);patient satisfaction (assessed using the satisfaction questionnaire); | — |
Countries
China
Contacts
Public ContactYan Zhenyi
Affiliated Hospital of Guangdong Medical University
Outcome results
None listed