post-herpetic neuralgia
Conditions
Interventions
group tSCS:Implanting spinal cord electrical stimulation
group tSCS+O3:Implanting spinal cord electrical stimulation and Ozonated Autohemotherapy
Sponsors
The First Peoples Hospital of Foshan
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria agreed upon by Chinese experts for the diagnosis and treatment of PHN, with a rash onset time within 1 year 2. PHN pain patients aged 50-80 years old, male or female, not limited 3. Except for the head and face, all trunk and limb areas have spinal nerve innervation (C4-L5) 4. Hospitalized patients with oral Pregabalin (150-300mg/d) VAS score>=4, or experiencing pain outbreaks = 3 times a day 5. Improve the neuropathic pain assessment scale ID Pain DN-4, Consider the nature of the pain as neuropathic pain 6. The subjects are able to follow the doctor's instructions for medication and surgical treatment, and accept the visit plan; Understand the content of the survey questionnaire, or be able to complete the survey questionnaire with the assistance of the interviewer 7. No contraindications for autoimmune trioxides in the blood
Exclusion criteria
Exclusion criteria: 1. In general, if the situation is poor, or if there is a serious systemic infection or HIV infection, respiratory dysfunction, etc., it is not possible to cooperate actively 2. Individuals with allergic diseases and those with an allergic constitution 3. History of drug sensitivity to drugs with similar structures (Pregabalin, OxyContin) 4. Epilepsy patients and those with a family history of epilepsy; Patients with contraindications related to experimental drug surgery, such as severe peptic ulcer, pancreatitis, intestinal obstruction, asthma, etc 5. Patients who suspect or have a history of drug abuse 6. Patients who have participated in drug trials within 3 months prior to the experiment (including the investigational drug) 7. For those who need to take analgesic drugs due to the combination of other neurological diseases 8. Contraindications for spinal cord electrical stimulation surgery exist 9. Patients who cannot tolerate electrode placement operations 10. Severe mental or other illnesses that cannot be accurately rated for pain or cannot objectively describe symptoms 11. Unable to follow up on schedule 12. Patients with tumor diseases or autoimmune diseases 13. There are contraindications for high oxygen levels in the blood, such as favism; Hyperthyroidism; Abnormal coagulation function; Unstable period of severe cardiovascular disease; Anemic patients; Pregnant women, especially those in the early stages of pregnancy; Diseases of unknown causes such as neurosis; Use angiotensin-converting enzyme inhibitors to treat patients; Medical oxygen allergy patients, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| visual analogue scale;pittsburgh sleep quality index;patient health questionnaire;generalised anxiety disorder assessment;the MOS item short from health survey; | — |
Countries
China
Contacts
Public ContactHuang Xiang
The First Peoples Hospital of Foshan
Outcome results
None listed