Colorectal Cancer
Conditions
Interventions
Lidocaine group:Lidocaine was given 1.5 mg/kg at the time of anesthesia induction, followed by 2 mg/kg/h pumping immediately until the end of the operation.
Blank control group:Conventional general anesthesia induction + equal volume normal saline +
conventional anesthesia + intraoperative continuous pumping of equal volume normal saline
Sponsors
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1)Prior to the initiation of any trial-related activities, the subject shall obtain informed consent, fully understand the purpose and significance of the trial, and be willing to comply with the trial protocol; 2)18 years old to 75 years old; 3)The patients were classified as American Society of Anesthesiologists (ASA) grade I-III; 4)Patients undergoing laparoscopic radical surgery for colorectal cancer; 5)BMI:18 to 28 kg/m2.
Exclusion criteria
Exclusion criteria: 1)Weight less than 40kg; 2)History of local anesthetic allergy,such as lidocaine; 3)Preoperative fatigue; 4)Psychiatric and cognitive disorders and a history of epilepsy; 5)With cardiovascular disease (congenital heart disease, bradycardia, hypotension, heart block, etc.) 6)With a history of myasthenia gravis; 7)Participated in other clinical trials (received the experimental drug or placebo) within 3 months prior to surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Identity consequence fatigue scale;Christensen fatigue score; | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS pain score;CRP concentration;the number of times the analgesic pump is applied in the 48 hours after surgery ;The first time of the postoperative exhaust ;General information included age, sex ratio (male/female), body mass index (BMI), American Society of Anesthesiologists Anesthesia Rating (ASA), nutritional screening risk (NRS2002) score, preoperative albumin concentration, preoperative hemoglobin concentration,operation duration,and duration of anesthesia;The first time to get out of bed;Incidence of postoperative nausea and vomiting;Incidence of postoperative tinnitus;Incidence of postoperative numbness of lips ; | — |
Countries
China
Contacts
Public ContactShangguan Wangning
The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
Outcome results
None listed