Lumbar disc herniation
Conditions
Interventions
Dexamethasone palmitate:According to the patients symptoms, signs and imaging findings, the affected nerve root was selected for epidural injection through the intervertebral foramen or lamina space.
Control group:Compound betamethasone
Sponsors
The First Affiliate Hospital of Soochow University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1)Age =18 years old; 2) unilateral pain in the buttock or below, with or without lumbago. 3) Lower limb pain is greater than low back pain, and NRS score =4. 4) Lumbar MRI or CT within 6 months confirmed the presence of lumbar disc herniation,
Exclusion criteria
Exclusion criteria: 1)Individuals allergic to the study drug. 2)Patients with a history of mental illness. 3)Patients who are unable to understand the study content, cannot cooperate with completing the questionnaires, or are unable to follow up. 4)Patients with concomitant diseases that may interfere with the assessment of efficacy (primarily conditions that may cause lower limb pain, such as Parkinson's disease, diabetic peripheral neuropathy, lower limb thrombosis, etc.). 5)Severe cardiovascular diseases that affect daily activities and interfere with functional assessments. 6)Unstable spondylolisthesis (vertebral displacement > 3mm or endplate angle change > 15° on dynamic lumbar X-rays), or grade III and above stable spondylolisthesis. 7)Severe osteoporosis with vertebral compression fractures in the segments intended for injection treatment. 8)Malignant tumors with spinal metastases. 9)Pregnant women, breastfeeding women, women planning pregnancy in the near future, or spouses planning pregnancy soon. 10)Other contraindications for injection therapy, such as infection at the puncture site, severe coagulopathy (e.g., gum bleeding), etc. 11)Having undergone an epidural injection in the past 3 months. 12)Patients with surgical plans within 3 months. 13)Platelet count less than 50 × 10?/L or those currently using anticoagulants or antiplatelet medications. 14)Patients with any of the following comorbidities: posterior capsule cataract, glaucoma, herpes simplex keratitis, poorly controlled diabetes (fasting blood glucose =7 mmol/L), recent acute myocardial infarction, peptic ulcers, tuberculosis, untreated infectious diseases, systemic fungal infections, electrolyte disturbances, recent abdominal surgery, or thrombotic conditions.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| pain intensity; | — |
Secondary
| Measure | Time frame |
|---|---|
| ODI score;Disability;Anxiety;depression; | — |
Countries
china
Contacts
Public Contactjinxiaohong
The First Affiliate Hospital of Soochow University
Outcome results
None listed