Neonatal intestinal flora
Conditions
Interventions
intervention group:Implementation of Early Essential Newborn Care
control group:Implementation of routine in-hospital care measures
Sponsors
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial Hospital)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Full-term post cesarean section neonates, gestational age >=37 weeks, <42 weeks 2. Guardian informed consent 3. Mother and baby in the same room after birth, total enteral feeding
Exclusion criteria
Exclusion criteria: 1. Neonates who are on antibiotics or need to be kept under observation or transferred to the neonatal ward due to birth asphyxia or other diseases; 2. Mothers with a history of alcohol consumption, smoking, illegal drug use during pregnancy or signs of infection such as prenatal fever, premature rupture of membranes >18h, chorioamnionitis, etc; 3. The mother has taken probiotic preparations within 1 month before delivery; 4. Incomplete important clinical data; 5. Guardians who withdraw midway or refuse to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diversity of microflora;microbial community richness;Effects of colony abundance and differentiation at various taxonomic levels; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal microecological metabolic gene differences and differential expression of intestinal short-chain fatty acids;Breastfeeding time, exclusive breastfeeding rate, and hypoglycemia, hypothermia, etc.;Follow-up for respiratory and digestive tract infections, documented observations of eczema, indigestion, and milk protein allergy;Intrinsic linkages of physiological indicators and functional differences in expressed and metabolized genes across ecological niches of the bacterial community; | — |
Countries
China
Contacts
Public ContactChenxiaoqing
The First Affiliated Hospital of Nanjing Medical University (Jiangsu Provincial Hospital)
Outcome results
None listed