scar
Conditions
Interventions
norm skin:no
inflammatory phase wound:no
proliferating phase skin:no
scar skin:no
Sponsors
First Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 76 Years
Inclusion criteria
Inclusion criteria: Group 1: Control Group (Normal Skin Discarded During Emergency Debridement and Suturing Process) Inclusion criteria (meeting one of the following): 1. Patients with III-degree full-thickness wounds (full-thickness injury) resulting from trauma occurring within 6 hours. 2. Patients requiring full-thickness skin grafting. Group 2: Inflammatory Phase Group (Wound Skin Discarded During Debridement and Suturing Process) Inclusion criteria: 1. Patients with acute trauma and III-degree full-thickness wounds (full-thickness injury) resulting from trauma occurring more than 12 hours, but within 72 hours. Group 3: Proliferative Phase Group (Wound Skin Discarded During Debridement and Suturing Process) Inclusion criteria: 1. Patients with acute traumatic wounds exceeding 48 hours, requiring re-debridement and suturing of III-degree full-thickness wounds (full-thickness injury). Group 4: Maturation Phase Group (Scar Specimens Removed During Scar Excision Surgery) Inclusion criteria: Patients clinically diagnosed with scars and requiring surgical excision of the scar.
Exclusion criteria
Exclusion criteria: Group 1: Control Group (Normal Skin Discarded During Emergency Debridement and Suturing Process) Exclusion criteria (meeting one of the following): 1. Patients with conditions such as hypertension, diabetes, or other factors that may affect wound healing. 2. Pregnant or breastfeeding women. Group 2: Inflammatory Phase Group (Wound Skin Discarded During Debridement and Suturing Process) Exclusion criteria (meeting one of the following): 1. Patients with conditions such as hypertension, diabetes, or other factors that may affect wound healing. 2. Pregnant or breastfeeding women. 3. Patients with burn wounds, chemical injuries, ulcerative wounds, or radiation-induced wounds. Group 3: Proliferative Phase Group (Wound Skin Discarded During Debridement and Suturing Process) Exclusion criteria (meeting one of the following): 1. Patients with conditions such as hypertension, diabetes, or other factors that may affect wound healing. 2. Pregnant or breastfeeding women. 3. Patients with burn wounds, chemical injuries, ulcerative wounds, or radiation-induced wounds. Group 4: Maturation Phase Group (Scar Specimens Removed During Scar Excision Surgery) Exclusion criteria (meeting one of the following): 1. Patients with conditions such as hypertension, diabetes, or other factors that may affect wound healing. 2. Pregnant or breastfeeding women. 3. Patients with burn wounds, chemical injuries, ulcerative wounds, or radiation-induced wounds.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression Levels of HMOX1;Expression Levels of GSF;Expression Levels of S100A4 ;Expression Levels of CXCL2;RNA-seq; | — |
Countries
China
Contacts
Public ContactJiaping Zhang
First Affiliated Hospital of Army Medical University
Outcome results
None listed