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Effect and mechanism of HF-rTMS based on the bimodal balance-recovery model of the unaffected hemisphere on patients with global aphasia after left massive cerebral infarction

Effect and mechanism of HF-rTMS based on the bimodal balance-recovery model of the unaffected hemisphere on patients with global aphasia after left massive cerebral infarction

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2400093943
Enrollment
Unknown
Registered
2024-12-13
Start date
2024-02-19
Completion date
Unknown
Last updated
2024-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

complete aphasia after left massive cerebral infarction

Interventions

Group 2:High-frequency (10Hz) repetitive Transcranial Magnetic Stimulation

Sponsors

China Rehabilitation Research Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.In line with the diagnostic criteria of the 2019 edition of "Diagnostic Points of Various Major cerebrovascular Diseases in China"; 2.According to the WAB diagnostic criteria for complete aphasia: Aphasia quotient<93.8 points, speech fluency 0-4 points, listening comprehension 0-3.9 points, retelling 0-4.9 points, naming 0-6 points; 3.First onset, single lesion; 4.Age 18-70 years old; 5.The course of the disease is more than 1 month, and the language function is normal before the onset of the disease; 6.Primary school or above education, right handed; 7.Stable condition, clear consciousness, no visual impairment or spatial neglect, no severe cognitive impairment, able to cooperate in completing treatment; 8.The patient or their family members are willing to accept this trial and sign the "Clinical Trial Informed Consent Form".

Exclusion criteria

Exclusion criteria: 1.Patients with speech disorder before the onset of the disease or with severe dysarthria; 2.Speech disorders caused by other neurodegenerative diseases such as dementia, Parkinson's disease, motor neurone disease, etc. 3.Those who have severe cognitive dysfunction and cannot cooperate with examination and rehabilitation training; 4.Combined with epilepsy, severe liver and kidney dysfunction or other serious physical diseases; 5.There is a metal foreign body or any other electronic device implanted in the body.

Design outcomes

Primary

MeasureTime frame
Results of the Western Aphasia Battery (WAB);

Secondary

MeasureTime frame
Results of fNIRS test;

Countries

China

Contacts

Public ContactHU Xueyan

China Rehabilitation Research Center

13691121960@163.com+86 10 87569419

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026