Alzheimers disease
Conditions
Interventions
tACS active group:tACS simultaneously combined with N-back task-training
tACS sham group:sham tACS simultaneously combined with N-back task-training
rTMS active group:rTMS
rTMS sham group:sham rTMS
Sponsors
Department of Psychiatry, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
55 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) confirmation of a probable AD diagnosis in accordance with the Diagnostic and Statistical Manual of Mental Disorders, 5th edition; (2) attainment of a Clinical Dementia Rating (CDR) score ranging from 0.5 to 2; (3) age falling within the range of 55 to 85 years; and (4) right-handedness.
Exclusion criteria
Exclusion criteria: (1) had been diagnosed with severe cardiac, pulmonary, hepatic, or renal disorders; (2) had a history indicative of significant cranial trauma, neurological or psychiatric illnesses; (3) exhibited evidence of focal brain lesions in T1 or T2 images; (4) displayed contraindications for TMS or tACS, such as the presence of medical implants or devices, or metallic elements within the body.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The level of cognitive function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neuropsychiatric condition;cognitive level; | — |
Countries
China
Contacts
Public ContactChen Wei
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
Outcome results
None listed