Colorectal cancer
Conditions
Interventions
Non-high-risk colorectal adenoma group:N/A
High-risk colorectal adenoma group:N/A
Sponsors
The First Medical Center of the General Hospital of the People's Liberation Army
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged 18–75 years; 2.No history of other malignant tumors; 3.No antibiotic treatment within three months prior to the start of treatment; 4. Must sign an informed consent form and agree to undergo relevant examinations and follow-up; 5. Must have a moderate to good physical condition to complete the study procedures; 6. Must agree to provide external hospital endoscopy reports. High-risk colorectal adenoma group: Diagnosis requires meeting at least one of the following criteria: Adenoma diameter = 10 mm; Pathological diagnosis of villous or tubulovillous adenoma; Pathology indicating high-grade dysplasia; Number of adenomas = 3. Non-high-risk colorectal adenoma group: Pathological diagnosis of adenoma but without the characteristics of high-risk colorectal adenomas mentioned above. Colorectal cancer group: Diagnosed with colorectal cancer via colonoscopy, with no prior radiotherapy, chemotherapy, or surgical treatment. Healthy control group: Healthy individuals aged 18–75 years were selected as controls.
Exclusion criteria
Exclusion criteria: 1. Patients with hereditary colorectal cancer; 2. Presence of severe systemic diseases such as cardiovascular, respiratory, or urinary system disorders; 3. Autoimmune diseases such as systemic lupus erythematosus or rheumatoid arthritis; 4. Recent history of acute infectious diseases or gastrointestinal infections; 5. Underwent surgery causing significant intestinal changes within the past year; 6. Long-term use of hormones, immunosuppressants, or other medications affecting the gut microbiota within the past three months; 7. Pregnant or breastfeeding women; 8. Coagulation disorders, contraindications to discontinuing anticoagulant medication, or related hematological disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fecal metagenomic sequencing results;Fecal metabolomics results; | — |
Secondary
| Measure | Time frame |
|---|---|
| Complete blood count ;Serological laboratory tests;The results of HE staining of intestinal tissues;Gene expression analysis of intestinal tissues;Dietary tolerance;Gastrointestinal symptoms;Bowel movement status;Exhaust situation;Incidence of newly developed polyps on endoscopy (if any); | — |
Countries
China
Contacts
Public ContactGang Sun
The First Medical Center of the General Hospital of the People's Liberation Ar
Outcome results
None listed