Vasovagal syncope
Conditions
Interventions
responders to metoprolol:metoprolol
non-responders to metoprolol:metoprolol
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 18 Years
Inclusion criteria
Inclusion criteria: Age 5-18 years; diagnosed with vasovagal syncope and treated with oral metoprolol [0.5 mg/(kg·day), divided into 2 doses, with a maximum dose not exceeding 2 mg/(kg·day)] for 2-3 months. Comprehensive demographic characteristics, clinical data, laboratory data, and follow-up data. All patients were treated at three research centers between January 2017 and September 2022. Follow-up was conducted via telephone, and informed consent was obtained from the parents or guardians, and from patients who had reached adulthood.
Exclusion criteria
Exclusion criteria: Subjects with organic cardiovascular and neurological diseases, metabolic disorders, or psychogenic disorders. Heart rate below 45 beats per minute or atrioventricular block. Legal guardians of the child refused participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Frequency of syncope, syncope symptom scores.;Hemodynamic types during the head-up tilt test (HUTT) (vasodepressor type, cardioinhibitory type, mixed type);Supine heart rate ;increase in heart rate before a positive response in HUTT;supine peripheral vascular resistance;supine cardiac output;increase in cardiac output before a positive response in HUTT;ECG P-wave dispersion;heart rate variability (frequency domain and time domain indices);changes in baroreflex sensitivity during HUTT;Echocardiographic measurements of chamber diameters, cardiac output, stroke volume;Various biochemical blood indices, serum uric acid;24-hour urine output, amounts of sodium, potassium, and chloride ions in 24-hour urine, urine pH value, urinary tyrosine;vasoactive molecules ; | — |
Countries
China
Contacts
Public ContactJunbao Du
Peking University First Hospital
Outcome results
None listed