Chronic hepatitis B
Conditions
Interventions
Observation group:None
Sponsors
Fifth Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
14 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.HBsAg positive greater than 6 months and HBV DNA positive, persistent or intermittent ALT / AST levels increased; 2.In HBV-infected patients over 14 years of age and under 65 years old; 3.Nucleoside (acid) analogues or interferon treatment in patients with CHB; 4.Voluntary participation in this study, and signed the informed consent form;
Exclusion criteria
Exclusion criteria: 1.Women who are pregnant or who are preparing for pregnancy and lactation; 2.Patients were unable or unwilling to follow the study protocol and complete the follow-up; 3.The patient is participating in other clinical trials and may affect data collection for this study; 4.Patients with concurrent HCV infection, HIV infection, liver cancer or cirrhosis, and autoimmune hepatitis; 5.Diseases associated with other major organs, such as severe heart disease or kidney disease; 6.There was a history of malignancy, including hepatocellular carcinoma, carcinoma in situ, and atypical hyperplastic nodules; 7.Suffers from mental illness; 8.Received corticosteroids, immunosuppressants, or chemotherapeutic agents within 6 months prior to enrollment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBeAg seroconversion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| HBsAg seroconversion rate, liver cancer and cirrhosis incidence; | — |
Countries
China
Contacts
Public ContactZhongsi Hong
Fifth Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed