Clinical study of ketoprofen gel paste for pain relief after minimally invasive arthroscopic surgery for knee osteoarthritis: a randomized controlled trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2400093878

Enrollment

Unknown

Registered

2024-12-13

Start date

2024-12-16

Completion date

Unknown

Last updated

2024-12-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

osteoarthritis

Interventions

Experimental group:Ketoprofen gel paste

Control group:Loxoprofen sodium gel paste

Blank group:Conventional treatment, no topical plaster

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: (1) The subjects voluntarily agree to participate in the study and sign a written informed consent; (2) Age 18-75 years old, male or female; (3) Patients undergoing minimally invasive arthroscopic surgery for osteoarthritis; (4) According to Kellgren-Lawrence imaging grades, grades 0 to I belong to the early stage; Class II ~ III belongs to the middle stage; Grade IV belongs to the late stage, and this study selects grade II to III; (5) The study/control drugs used by the patient were included in the drug list specified in this study.

Exclusion criteria

Exclusion criteria: (1) previous treatment that may affect the efficacy; (2) Patients with a history of arthritic diseases such as rheumatism, rheumatoid arthritis, gouty arthritis, or limited lower limb function due to trauma; (3) fracture, dislocation, etc.; Accompanied by tumors, cardiovascular and cerebrovascular diseases, blood diseases and other serious primary diseases, or accompanied by mental disorders and communication disorders can not determine the efficacy. Radiating pain or dysfunction caused by other diseases (visceral organ diseases, cardiovascular and cerebrovascular diseases); (4) Patients who are allergic to NSAIDs, allergic to NSAIDS, and patients with serious skin damage around the knee joint; (5) Pregnant and lactating women or women of childbearing age who are trying to conceive; (6) Other situations in which the researcher considers it inappropriate to participate in this experiment

Design outcomes

Primary

Measure	Time frame
Total effective rate;	—

Secondary

Measure	Time frame
VAS score;WOMAC score;Knee Lysholm score;Time for swelling pain to subside;Swelling degree;satisfaction;Comfort level;	—

Countries

China

Contacts

Public Contactwang zhihua

The First Affiliated Hospital of Kunming Medical University

754746206@qq.com+86 137 0830 2754

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026