Left Ventricular Diastolic Dysfunction
Conditions
Interventions
Individualized PEEP group:PEEP=PEEP level at lowest driving pressure
Fixed PEEP group:PEEP =5cm H2O
Sponsors
Shengjing Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients undergoing laparoscopic colorectal surgery under elective general anesthesia from December 2024 to December 2025, aged >= 65 years, with an expected operation time of more than 2 hours, ASA grade I-III, and patients diagnosed with LVDD by preoperative cardiac ultrasound, were selected.
Exclusion criteria
Exclusion criteria: BMI >30kg/m^2, history of pulmonary or upper respiratory tract infection in the past two weeks, chronic obstructive pulmonary disease requiring oxygen, lung cancer, history of thoracic surgery, thoracic deformity, pneumothorax, large pleural effusion, pulmonary bullae, combined with severe liver and kidney insufficiency (serum creatinine concentration >186umol/L, bilirubin concentration >20umol/L or albumin concentration <30g/L), neuromuscular dysfunction, severe valvular disease, LVEF <50%, postoperative plan not to extubate, serious complications such as massive bleeding, anaphylactic shock, embolism and so on.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Myocardial Performance Index;Oxygenation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percent change in early peak velocity e' in mitral annular diastole? e';Mitral orifice early diastolic peak velocity/mitral annular diastolic early peak velocity e'E/e';Mitral annulus plane systolic excursion(MAPSE);Tricuspid Annular Plane Systolic Excursion(TAPSE);Inferior vena cava collapse index(IVC);Postoperative pulmonary complications(PPCs);Postoperative cardiovascular complications;Intraoperative vasopressors;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactNan Guo
Shengjing hospital of China Medical University
Outcome results
None listed