None
Conditions
Interventions
Diprivan group:Induction and maintenance of anesthesia with Diprivan
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: (1) Age 18 to 65 years, regardless of gender, BMI = 18~30 kg/m²; (2) ASA I-III classification; (3) Patients scheduled for elective non-cardiothoracic, non-neurosurgical surgeries under general anesthesia, with an expected duration of surgery >=2 hours and requiring endotracheal intubation; (4) Able to understand the study procedures and voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) History of anesthetic complications; (2) Hepatic dysfunction (ALT or AST >= 2.5 times the upper limit of normal, TBIL >= 1.5 times the upper limit of normal); (3) Renal dysfunction (Cr > upper limit of normal, or dialysis treatment within 28 days prior to surgery); (4) Known allergy or contraindication to the investigated drug or other anesthetic agents; (5) Pregnant or breastfeeding women; (6) Any other factors deemed by the investigator to be unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of both anesthesia induction and maintenance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of successful anesthesia induction;Duration of eyelash reflex disappearance;Investigating the duration proportion of BIS values maintained within the range of 40-60 from the onset to the end of drug maintenance;The time from discontinuation of anesthesia maintenance drugs to patient awakening;Extubation time;The time from discontinuation of anesthesia maintenance drugs to patient readiness for discharge (the operating room or post-anesthesia care unit);Perioperative Hemodynamic Status;Incidence and Severity of Postoperative Delirium;Adverse Reaction Occurrence;Medication Utilization;Pharmacokinetic (PK) Parameters;Incidence of Movement During Anesthesia Maintenance;Incidence of Hypotension or Hypertension During Anesthesia;Incidence of Postoperative Respiratory Depression;Incidence of Injection-Site Pain ;The Occurrence of Paresthesia; | — |
Countries
China
Contacts
Public ContactChan Chen
West China Hospital of Sichuan University
Outcome results
None listed