Postoperative analgesia
Conditions
Interventions
Oxelidine no background dose group (Group A):30 mg oxelidine + normal saline + (3 antiemetics such as granisetron 9 mg) ?100 ml. The first load dose was intravenous injection of 1.5 mg, followed by pa
Oxellidine background dose group (Group B):30 mg oxelidine + normal saline + (3 antiemetics such as granisetron 9 mg) ?100 ml. The first dose was 0.2-0.4 mg/kg oxelidine + (3 antiemetics such as grani
Sufentanil group (Group C):30 mg oxelidine + normal saline + (3 antiemetics such as granisetron 9 mg) ?100 ml. The first dose was 100 µg sufentanil + normal saline + (3 antiemetics such as granisetron
Sponsors
Zigong Fourth People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients ranged in age from 18 to 65. No gender limitation; American Association of Anesthesiologists (ASA) Level I-III for Medical conditions; Patients undergoing thoracoscopic lobectomy.
Exclusion criteria
Exclusion criteria: Patients with obstructive sleep apnea hypopnea syndrome (OSAHS); Combined with allergic disease; Patients currently using or dependent on opioids; Patients with chronic pain (including patients with cancer pain before surgery); Patients with severe cardiopulmonary dysfunction; Severe heart, liver or kidney dysfunction; Specific type of surgery or disease state; Patients undergoing thoracotomy for various reasons; Patients with delayed extubation after operation; Patients who are participating in other studies; Mental disorder or speech communication disorder; Patients who refuse to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The number of times of moderate to severe pain in the 24 hours after surgery (NS > 4 requiring pain relief assistance was defined as 1 episode of moderate to severe pain).; | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS scores were obtained at 4 h, 24 h, and 72 h after surgery;PCA press times;Adverse reactions: nausea, vomiting, respiratory depression, drowsiness;First time out of bed after surgery;Time of first postoperative defecation;Patient satisfaction with analgesia;Hospital stays;Antiemetics and glucocorticoids are allowed when nausea and vomiting occur; | — |
Countries
China
Contacts
Public ContactLu Bin
Zigong Fourth People's Hospital
Outcome results
None listed