Preeclampsia
Conditions
Interventions
Aspirin dose adjustment intervention group:The dose of aspirin was adjusted according to the platelet aggregation rate (women with aspirin resistance was adjusted to 150mg per day at bedtime)
Routine treatment group:Aspirin 100mg was taken orally before going to bed daily.
Sponsors
Obstetrics and Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Over 18 years old; 2. Singleton pregnancy; 3. 11 weeks ~ 13 weeks and 6 days ultrasound showed fetal survival, which was calculated as high risk (> 1:100) according to the preeclampsia screening algorithm of the Fetal Medical Foundation.
Exclusion criteria
Exclusion criteria: 1. Severe fetal abnormalities found during ultrasound scan at 11 weeks ~ 13 weeks and 6 days of pregnancy; 2. Unviable fetus (spontaneous abortion or stillbirth) 3. Treatment with aspirin within 28 days before NT ultrasound screening; 4. Bleeding disorders (such as von Willebrand disease, peptic ulcer, hypersensitivity to aspirin); 5. Long-term use of non-steroidal anti-inflammatory drugs; 6. Participated in another drug trial within 28 days prior to screening; 7. Refusal to take aspirin; 8. Poor aspirin adherence (medication rate <85%).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of preterm (<37 weeks) preeclampsia; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidences of pre-eclampsia, gestational hypertension and non-pre-eclampsia intrauterine growth restriction at <34 weeks and =37 weeks;Incidences of gestational hypertension and non-pre-eclampsia intrauterine growth restriction at <37 weeks ; | — |
Countries
China
Contacts
Public ContactWeirong Gu
Obstetrics and Gynecology Hospital of Fudan University
Outcome results
None listed