sepsis
Conditions
Interventions
Intervention group:Patients in the intervention group will receive a ketogenic formula with 8g of carbohydrates per 100g.
Control group:The control group received Peptisorb enteral nutrition solution
Sponsors
Northern Jiangsu People's Hospital Affiliated to Yangzhou University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Age >= 18 years; Meets the Sepsis 3.0 diagnostic criteria; Sepsis diagnosis within 72 hours at the time of enrollment; Enteral nutrition is feasible within 48 hours of ICU admission; Informed consent obtained from the patient or their guardian.
Exclusion criteria
Exclusion criteria: Pregnancy or breastfeeding; Autoimmune diseases; Severe liver dysfunction or liver failure: Child-Pugh class C; Refractory metabolic acidosis: pH < 7.0 and persistent for more than 2 hours, difficult to correct; Presence of contraindications for enteral nutrition; Allergic to components of enteral nutrition.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sequential Organ Failure Assessment; | — |
Secondary
| Measure | Time frame |
|---|---|
| ketone bodies;Intensive Care Unit Mortality Rate;Hospital mortality rate;Length of ICU stay;Length of hospital stay;Demand for vasoactive drugs;Mechanical ventilation rate;Duration of mechanical ventilation;lactate;glucose;Acute Physiology and Chronic Health Evaluation;levels of inflammatory cytokines;Acid-base balance;Rate of Continuous Renal Replacement Therapy;Duration of Continuous Renal Replacement Therapy;urine output per 24 hours.; | — |
Countries
China
Contacts
Public ContactJiangquan Yu
Northern Jiangsu People's Hospital Affiliated to Yangzhou University
Outcome results
None listed