None
Conditions
Interventions
Ciprofol Youth Group:Intravenous injection of ciprofol at 0.4 mg/kg during anesthesia induction, and continuous infusion of ciprofol at 0.8 mg/kg/h during anesthesia maintenance.
Ciprofol elderly Group:Intravenous injection of ciprofol at 0.4 mg/kg during anesthesia induction, and continuous infusion of ciprofol at 0.8 mg/kg/h during anesthesia maintenance.
Sponsors
General Hospital of the Southern Theater of Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
25 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Young group (aged 25 to 45) and elderly group (aged 65 to 85); 2. Patients undergoing elective geriatric orthopedic surgery with general anesthesia; 3. ASA physical status classification I to III; 4. Informed consent, voluntary participation in the trial, and signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals with severe cardiac, pulmonary, hepatic, or renal dysfunction and coagulation abnormalities; 2. Those with a history of mental illness or long-term use of psychiatric medications (dementia, schizophrenia), chronic analgesic medication history, or history of alcohol abuse; 3. Participants who have been involved in another clinical drug study within the past 6 months; 4. Individuals allergic to the trial medication; 5. Pregnant or breastfeeding women; 6. Surgical blood loss exceeding 800 ml.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The plasma concentration of ciprofol at each time point; | — |
Secondary
| Measure | Time frame |
|---|---|
| Various pharmacokinetic parameters;Hemodynamic effects of ciprofol;Dose-response relationship of ciprofol;Perioperative adverse events;Age, gender, height, weight, ideal weight and body mass index;Biochemical indexes such as liver and kidney function before and after operation; | — |
Countries
China
Contacts
Public ContactXu Bo
Department of Anesthesiology, General Hospital of the Southern Theater of Chinese People's Liberation Army
Outcome results
None listed