insulin resistance or type 2 diabetes
Conditions
Interventions
Test group:Laparoscopic sleeve gastrectomy(LSG) + Semaglutide
Control group:Laparoscopic sleeve gastrectomy(LSG)
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 16-65 years, BMI >= 27.5 kg/m²; 2.Diagnosed with insulin resistance (Homeostasis Model Assessment of Insulin Resistance index HOMA-IR > 2.69) or type 2 diabetes (HOMA-IR = FPG × FINS / 22.5); 3.Signed informed consent and complete follow-up data from our hospital.
Exclusion criteria
Exclusion criteria: 1. Type 1 diabetes, secondary diabetes, gestational diabetes; 2. History of weight loss surgery or use of other weight loss drugs or medical procedures such as liposuction within 90 days prior to enrollment; 3. History of acute or chronic pancreatitis; 4. Personal or family history of medullary thyroid carcinoma (MTC); 5. Poorly controlled mental disorders or refusal to participate in follow-up assessments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| excess weight loss percentage (EWL%) after 6 months post-surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of insulin resistance or remission of type 2 diabetes;Adverse events;36-Item Short Form Survey (SF-36); | — |
Countries
China
Contacts
Public ContactChen Yi
West China Hospital, Sichuan University
Outcome results
None listed