Acute myocardial infarction combined with heart failure
Conditions
Interventions
Experimental group:Sacubitril valsartan sodium combined with cardiac rehabilitation
Control group:Sacubitril valsartan sodium
Sponsors
Yulin First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. It met the diagnostic criteria of acute myocardial infarction combined with heart failure in the 2019 Guidelines for the Diagnosis and Treatment of Acute Myocardial Infarction, and was confirmed by electrocardiogram, ultrasound and biochemical examination; Killip was graded ?~?. 3. No history of myocardial infarction or heart failure; 4. Have not undergone major heart surgery; 5. Patients who can tolerate therapeutic drugs and have no history of drug sensitivity.
Exclusion criteria
Exclusion criteria: 1. Exclude heart failure and cardiac enlargement caused by papillary muscle dysfunction, ventricular septal perforation and isolated ventricular aneurysm, except for patients with liver and renal insufficiency and other serious organic diseases; 2. Hemodynamic instability; 3. Blood and immune system diseases; 4. Patients who cannot tolerate ARNI (hypotension, angioneurotic edema, creatinine significantly increased) are excluded; 5. Dropping out of research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NT-ProBNP;Cardiac necrosis markers;Left ventricular ejection fractions;Left ventricular end-diastolic dimension,LVED;Left atrial diameter,LAD;Anaerobic threshold oxygen uptake,VO2 AT;Peak oxygen uptake ,VO2 peak;Metsablic equivalent,Mets; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of comorbidities; | — |
Countries
China
Contacts
Public ContactZhao Yanmei
Yulin First People's Hospital
Outcome results
None listed