Persistent Pulmonary Hypertension of the Newborn
Conditions
Interventions
PPHN was not treated with iNO in the group:None
PPHN treated with iNO treatment group:None
Sponsors
Shenzhen Baoan Women's and Children's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Newborns born with a gestational age of >= 22 weeks; 2. Admitted to the NICU within 7 days after birth; 3. Respiratory distress requiring noninvasive/invasive ventilator support; 4. Oxygen concentration> 40%.
Exclusion criteria
Exclusion criteria: 1. Cyanotic congenital heart disease; 2. Children born with significant malformations (malformations that do not generally cause PPHN but that predispose the child to death or parental abandonment of treatment, e.g., Pierre-Robin Syndrome, Marfan Syndrome, etc.); 3. Patients with severe hemorrhage, e.g., pulmonary hemorrhage, grade >=2 intracranial hemorrhage (IVH), clearly identified prior to admission; 4. Chromosomal diseases; 5. Patients with metabolic disorders; 6. Automatic discharge or transfer to a hospital other than a participating center; 7.Those who refused to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| early death;Moderate to severe neurodevelopmental disorders;late deaths; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of invasive ventilator ventilation;Duration of oxygen therapy;restriction in growth;hearing impairment;visual impairment;motion damage;Griffiths score; | — |
Countries
China
Contacts
Public ContactZhang Lian
Shenzhen Baoan Women's and Children's Hospital
Outcome results
None listed