Postoperative Pain Sensitization and Chronic Pain
Conditions
Interventions
Intervention Group (K Group):At the end of the surgery, under ultrasound guidance, a thoracic paravertebral nerve block is performed. A total of 20?ml of nerve block solution is injected, consisting o
Control group (C group):At the end of the surgery, under ultrasound guidance, a thoracic paravertebral nerve block is performed by injecting 20?ml of a nerve block solution consisting of 0.25% ropivac
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-65 years old, gender is not limited; ASA classification I-III; 30 kg/m^2 >= BMI > 18kg/m^2. 2.Patients undergoing thoracoscopic surgery; if diagnosed with lung cancer, all cases must involve primary unilateral tumors without metastasis, scheduled for elective initial thoracoscopic surgery, and with no history of radiotherapy or chemotherapy. 3.Patients and their families must be fully informed about the study, provide consent, and sign the consent form.
Exclusion criteria
Exclusion criteria: 1.Patients unwilling to sign informed consent or refusing to cooperate before surgery. 2.Patients with severe dysfunction of vital organs such as the heart or lungs, or with a history of asthma, active gastrointestinal ulcers, or bleeding. 3.Patients with rheumatic or autoimmune systemic diseases requiring exogenous hormone therapy for maintenance. 4.Patients with uncorrected coagulation disorders. 5.Patients allergic or hypersensitive to the anesthetics and related drugs used in this study (e.g., esketamine, ropivacaine, propofol, atropine) or with a history of hypersensitivity. 6.Patients with a history of long-term or recent alcohol or narcotic drug abuse, or use of central nervous system depressants. 7.Patients with neurological, psychiatric disorders, or intellectual disabilities that impair their ability to learn and understand the NRS scoring system or to accurately describe their sensations, as well as patients unwilling to cooperate. 8.Postoperative patients refusing to participate in the clinical study or perform NRS scoring.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Pain Sensitization and Mechanical Pain Threshold in the Incision Area on Postoperative Day 1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Pain Sensitization and Mechanical Pain Threshold in the Incision Area on Postoperative Day 3;Incidence of Pain Sensitization and Mechanical Pain Threshold on the Medial Side of the Contralateral Forearm;Numeric Rating Scale (NRS) Score;Central Sensitization Inventory(CSI) Score;Interview version of the Neuropathic Pain Diagnostic Questionnaire(I-DN4) Score;Total Perioperative Opioid Consumption and Total Postoperative Rescue Analgesic Consumption;Pan-Immune Inflammation Value ,PIV; | — |
Countries
China
Contacts
Public ContactLihua Peng
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed