anaesthesia
Conditions
Interventions
Remimazolam group:Administer a loading dose of remimazolam at 0.10 mg/kg, followed by a maintenance dose of 0.20 mg/kg/h. Dynamically adjust with a dose gradient of 0.05mg/kg/h based on the level of s
Control group:Administer a loading dose of 0.9% sodium chloride injection at 0.10 ml/kg, followed by a maintenance dose of 0.20 ml/kg/h.
Sponsors
Affiliated Hospital of Jiangsu University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients scheduled for elective total hip arthroplasty due to hip fracture, regardless of gender, aged =65 years, with a body mass index (BMI) of 18~30 kg/m², and ASA classification I~III.
Exclusion criteria
Exclusion criteria: Patients with obvious respiratory or circulatory dysfunction, abnormalities in liver or kidney function, a Mini-Mental State Examination (MMSE) score <24 one day before surgery, pre-existing major neurological diseases such as Alzheimer's disease or dementia, psychiatric disorders such as depression or anxiety, potential or history of drug abuse or alcohol dependency, inability to cooperate (e.g., complete blindness, severe hearing loss, aphasia), allergies or contraindications to benzodiazepines or local anesthetics, and contraindications to spinal anesthesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium within three days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Delirium Subtypes;heart rate;Mean Arterial Pressure;The quality of sleep;postoperative pain score;Patient Satisfaction with Anesthesia;Blood Loss;bispectral index;Incidence of Adverse Reactions;Utilization of Vasoactive Drugs; | — |
Countries
China
Contacts
Public ContactWu Jin
Affiliated Hospital of Jiangsu University
Outcome results
None listed