Major depression disorder
Conditions
Interventions
Experimental group:Consume 1 package of probiotics daily (viable count >= 10^9CFU/day)
Control group:Consume 1 package of placebo daily
Sponsors
Mental Health Center Affiliated to Jiangnan University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. meet the diagnostic criteria for depressive disorder in DSM-5; 2. Chinese Han residents, aged 18 to 65 years old, male or female; 3. Primary school education or above; 4. Volunteer to participate in the study; 5. Hamilton's depression score >=17 points.
Exclusion criteria
Exclusion criteria: 1. Meet other diagnoses of DSM-IV axis I, such as schizophrenia, bipolar disorder, etc.; 2. Accompanied by poorly controlled serious physical diseases, such as coronary heart disease and thyroid dysfunction; 3. Have a history of craniocerebral trauma resulting in loss of consciousness, or a history of epilepsy; 4. There is significant finger motor dysfunction (inability to click the mouse); 5. Women who are pregnant or breastfeeding, or those who are preparing for pregnancy (childbearing); 6. Have used antibiotics, probiotics, or their products in the past 1 month; 7. Received ECT/MECT treatment in the last 6 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Temporal Experience of Pleasure Scale;Electroencephalogram detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton's Depression Scale-17;Hamilton anxiety scale;Blood-related inflammatory factors, brain-derived neurotrophic factors and other indicators were detected;Gastrointestinal symptom grading scale;Body Perception Questionnaire-Short Form; | — |
Countries
China
Contacts
Public ContactWang Jun
Mental Health Center Affiliated to Jiangnan University
Outcome results
None listed