Differentiated Thyroid Cancer
Conditions
Interventions
linea alba cervicalis approach operation:The affected thyroid gland lobe and isthmus excised and ipsilateral central lymph node dissection via cervical alba approach
sternocleidomastoid muscle approach operation:The affected thyroid gland lobe and isthmus excised and ipsilateral central lymph node dissection via sternocleidomastoid muscle approach
Sponsors
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Eligibility
Sex/Gender
All
Age
18 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years and <70 years; 2. Accept open thyroid surgery; 3. Preoperative judgment of single malignant thyroid tumor, diameter <= 1cm, confined to one side of the gland, no thyroid capsule or external gland invasion, no cervical lymph node metastasis indicated in imaging examination,and lobectomy+isthmectomy+central area cervical lymph node dissection of the affected side was planned; 4.Willing to participate in the study, comply with the study requirements and follow-up arrangements, and sign the ICF; 5. The researchers believe that the expected postoperative survival time of the subjects is not less than 12 months; 6. BMI<30 kg/m^2; 7. Preoperative ECOG(Eastern Cooperative Oncology Group)0/1; 8. Preoperative ASA(American Society of Anesthesiologists)I-III.
Exclusion criteria
Exclusion criteria: 1. Women in pregnancy or lactation at the time of screening; 2. Preoperative judgment of thyroid malignant tumor >1cm, or invasion of thyroid capsule or external gland, or lateral cervical lymph node metastasis; 3. Multiple thyroid malignant tumors or located in bilateral glands; 4. Thyroid isthmus tumor; 5. Suspected or confirmed medullary or undifferentiated thyroid carcinoma; 6. Have peripheral vascular diseases that affect blood supply of neck; 7. Active infectious collagen disease (such as scleroderma) or any other disease that may interfere with wound healing; 8. Diagnosed with diabetes; 9. History of coagulation dysfunction; 10. Being treated with oral or intravenous antibiotics for a pre-existing disease or infection; 11. Serious mental illness; 12. serious respiratory illness; 13. Severe cardiopulmonary insufficiency; 14. Severe hepatic and renal insufficiency; 15. History of unstable angina pectoris or myocardial infarction within 6 months; 16. History of cerebral infarction or cerebral hemorrhage within 6 months; 17. History of use of immunosuppressive drugs (such as steroids) within 6 months prior to enrollment; 18. Received chemotherapy or radiotherapy within 6 months prior to study enrollment, or was scheduled to receive chemotherapy or radiotherapy during the study period; 19. A personal or family history of keloid formation; 20. Currently participating in clinical studies of any other drug (within 30 days or within five half-lives of the experimental drug) or devices; 21. Surgical treatment for other diseases or emergency thyroid surgery is required at the same time; 22. Previous thyroid surgery history, excluding thyroid fine needle aspiration cytology; 23. Patients with hoarseness, vocal cord fixation and other nerve compression or injury before surgery; 24. Grade III goiter; 25. Renal impairment and hyperparathyroidism were observed before study enrollment; 26. For any other reason judged by the researcher as not suitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| operative complication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of incision appearance;Postoperative Quality of Life; | — |
Countries
China
Contacts
Public ContactWu Yijun
The FIrst Affiliated Hospital, College of Medicine, Zhejiang University
Outcome results
None listed