Non-Small Cell Lung
Conditions
Interventions
Chemotherapy group :None
Immune checkpoint inhibitor combination therapy group:None
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Men or women aged >=18 years. 2) Histologically or cytologically confirmed EGFR mutation-positive non-small cell lung cancer. 3) Received at least one TKI treatment and developed resistance. 4) ECOG physical status score of 0-2. 5) Patients must provide adequate medical records and imaging to assess efficacy and safety. 6) Patients must have at least one measurable lesion according to RECIST 1.1 criteria.
Exclusion criteria
Exclusion criteria: 1) EGFR mutation-positive patients with an indeterminate diagnosis of non-small cell lung cancer. 2) Other active malignancies within 5 years or concurrently. Cured limited tumors such as basal cell carcinoma of the skin, squamous carcinoma of the skin, superficial bladder cancer, carcinoma in situ of the prostate, carcinoma in situ of the cervix, and carcinoma in situ of the breast may be enrolled. 3) Have severe heart disease or unstable angina. 4) Patients with active autoimmune disease or requiring immunosuppressive therapy. 5) Have severe infections such as HIV, active tuberculosis or hepatitis. 6) Have severe mental illness or cognitive impairment that affects treatment decisions. 7) Women who are pregnant or breastfeeding. 8) Patients with a known history of psychotropic substance abuse or addiction; patients with a history of alcoholism.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| objective response rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| disease control rate;progression free survival;overall survival;Adverse Event; | — |
Countries
China
Contacts
Public ContactHe Yayi
Shanghai Pulmonary Hospital
Outcome results
None listed