ST-segment elevation myocardial infarction
Conditions
Interventions
Pretreatment PPCI strategy :20 mg prourokinase I.V. before PPCI
Immediate PPCI strategy:Immediate PPCI without pretreatment
Sponsors
Tianjin Chest Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) age: 18 or over and less than 75 years old; (2) symptom onset persisting for more than 20 minutes; (3) >=2 mm ST-segment elevation in 2 contiguous precordial leads, >=1 mm ST-segment elevation in 2 contiguous extremity leads; (4) symptom onset within 6 h before randomization; (5) willing to participate and completing the informed consent.
Exclusion criteria
Exclusion criteria: (1) Severe cardiovascular diseases, including: new left bundle branch block; Acute aortic syndromes; Known acute pericarditis and/or subacute bacterial endocarditis;Cardiogenic shock; PCI within previous 1 month or previous bypass surgery; Previously known coronary artery disease not suitable for revascularization; Hospitalisation for cardiac reason within past 48 hours; (2) Not suitable for thrombolytic therapy, including: Definite cerebral apoplexy history; Active bleeding or known bleeding disorder/diathesis; Any history of central nervous system damage (i.e. neoplasm, aneurysm, intracranial or spinal surgery) or recent trauma to the head or cranium (i.e. 125kg; Known hypersensitivity to any drug that may be used in the study; Inability to follow the protocol and comply with follow-up requirements or any other reason the investigator feels would place the patient at increased risk.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| complete epicardial and myocardial reperfusion; | — |
Secondary
| Measure | Time frame |
|---|---|
| TMPG 3;TFG 3;STR >= 70%;MACE;TMPG 3 and TFG 3 before wire crossing; | — |
Countries
China
Contacts
Public ContactLi Chunje
Tianjin Chest Hospital
Outcome results
None listed