Lumbar disc herniation
Conditions
Interventions
Control group (Group A):After the patient was monitored, the infusion was completed within 10 minutes with 1.0ug/kg dexmedetomidine as the load dose, and 1µg/kg fentanyl was given 5 minutes before the
Experimental group (Group B):After the patient was monitored, the infusion was completed within 10 minutes at 0.8µg/kg dexmedetomidine as the load dose, and then continued at 0.4~0.6µg/kg·h. The remif
Sponsors
Surgery Center, Department of Anesthesiology, The First Affiliated Hospital of Gannan Medical University, China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Select patients who meet the operative indications for percutaneous intervertebral arthroscopy and who consent to the operation; 2. American Society of Anesthesiologists grade I to II, age 18 to 60 years; 3. Patients were informed of this study and signed informed consent;
Exclusion criteria
Exclusion criteria: 1. Refuse to participate in this researcher; 2. Patients with vital organ dysfunction; 3. Patients with severe hypertension and diabetes; 4. Those allergic to dexmedetomidine and remifentanil; 5. Patients with severe bradycardia and conduction block; 6. A history of chronic pain, mental illness, alcohol or drug abuse; 7. Long-term use of sedative or analgesic drugs; 8. Myasthenia gravis or bronchial asthma; 9. body mass index (BMI)>28 or < 18kg/m2; 10. People with language and communication disabilities; 11. Pregnant or lactating patients 12. Patients entering the operating room with resting blood oxygen saturation (SpO2) <=95%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Observer's Assessment of Alertness/Sedation;Incidence of blood oxygen saturation less than 95% under 2L/min nasal catheter oxygen inhalation during operation and in the anesthesia recovery room; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale;Anesthesia recovery time;Duration of stay in anesthesia recovery room;Blood pressure;Heart rate;Respiratory rate;Mean arterial pressure;End-expiratory carbon dioxide;Respiratory depression;bradycardia;Nausea or vomiting;hypotension;Dry mouth;Patient satisfaction 4 hours after surgery;Total dosage of dexmedetomidine;The total amount of remifentanil used;Remedy drug application; | — |
Countries
China
Contacts
Public ContactGuoRui
First Affiliated Hospital of Gannan Medical University
Outcome results
None listed