Autism Spectrum Disorder
Conditions
Interventions
Treatment group :Umbilical cord mesenchymal stem cell derived exosomes nasal spray
Sponsors
The First Medical Centre, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
3 Years to 8 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for ASD in the Autism Diagnostic Observation Scale (ADOS); (2) Age 3-8 years old, male or female; (3) After excluding active inflammation in other sites, any of the cytokines IL-1, IL-2, IL-6, IL-8, IL-10 or TNF-a were more than 1.5 times higher than the upper limit of normal by serum cytokine detection; (4) No known immune deficiency diseases, blood routine, liver, kidney, heart, lung no major functional abnormalities; (5) Clinical study participants and/or guardians can fully understand the informed consent content of this study and voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) Patients with tumors or tumor history (including hematologic tumors and solid tumors); (2) previous history of severe allergic reaction, blood product allergy; (3) Autism and other mental disorders other than autism spectrum disorders due to active epilepsy, cerebrovascular disease or brain trauma; (4) Situations that other researchers consider inappropriate to be included in the group.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SRS scale;Vinland scale; | — |
Countries
China
Contacts
Public ContactYang Guang
The First Medical Centre, Chinese PLA General Hospital
Outcome results
None listed