Tuberculosis
Conditions
Interventions
Observation group:None
Sponsors
Shanghai Pulmonary Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Newly diagnosed untreated symptomatic (cough, weight loss, fever, etc.) patients with pulmonary tuberculosis 2. Be over 18 years of age 3. Able to understand and sign the informed consent form 4. At the same time, one of the adjustments must be met: a) Positive AFB smear - NTM is excluded b) Positive MTB culture, if DST is present, first-line drug resistance is not present c) Xpert MTB/RIF positive with no evidence of rifampicin resistance
Exclusion criteria
Exclusion criteria: 1. Drug susceptibility test (DST) shows resistance to first-line anti-tuberculosis drugs 2. Phenotypic DST does not match Xpert MTB/RIF 3. Anti-TB treatment history in the past year 4. Pregnancy or breastfeeding 5. Tuberculosis combined with extrapulmonary tuberculosis or non-tuberculous mycobacterial lung 6. Combined with hepatic, renal, metabolic, autoimmune diseases, endocrine, hematologic, neurologic diseases, other uncontrolled acute and chronic respiratory diseases. (e.g. AECOPD, asthma), mental illness, malignant tumors, long-term use of immunosuppressive drugs or HIV/AIDS. 7. Alcoholics (>10 years and >2 alcoholic beverages per day). 8. According to the researcher’s judgment, the patient has any diseases that are not suitable for this study or may prevent the patient from participating in the whole study. 9. Concurrent Participants in Other Clinical Studies
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Treatment success ;Xpert-MTB-HR Value Change Curve;Absorption of lung disease lesions at key time points; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sputum smear conversion status;6m relapse after the end of treatment;12m relapse after the end of treatment;Symptom and Sign Score; | — |
Countries
China
Contacts
Public ContactWei Sha
Shanghai Pulmonary Hospital
Outcome results
None listed