Atrial Fibrillation
Conditions
Interventions
Experimental group:2ml5% calcium chloride injection was injected into the autonomic ganglion tissue between the coronary sinus and the right upper pulmonary vein, the third fat pad, and the upper wall
Control group:2ml0.09% sodium chloride injection was injected into the autonomic ganglion tissue between the coronary sinus and the right upper pulmonary vein, the third fat pad, and the upper wall of
Sponsors
PLA Northern Theater General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for patients with HOCM were: maximum septal thickness >=15mm confirmed by echocardiography, peak pressure difference of left ventricular outflow tract >=50 mmHg at rest or excitation, and no improvement in symptoms after oral medication, except for other factors causing myocardial hypertrophy. 1)Aged 80-18 years, Sex Unlimited; 2)The following operations were performed at selected times: external circulation down transaortic incision ventricular septal partial myocardial resection, not directly mitral valve repair or mitral valve replacement; 3) EF > 40%;
Exclusion criteria
Exclusion criteria: 1) Patients with preoperative atrial fibrillation or atrial flutter, history of radiofrequency ablation, and preoperative installation of a pacemaker or defibrillator 2) History of second or multiple heart surgeries; 3) Patients with Morrow surgery combined with other cardiac operations; 4) Sick sinus syndrome, pre-excitation syndrome, atrioventricular block; People who need to take class I and Class III antiarrhythmic drugs; 5) Liver and kidney function damage (test results exceed 3 times the upper limit of normal value), there are contraindications for surgery; 6) Patients with other diseases requiring radiotherapy, chemotherapy or long-term hormone therapy; 7) Those who have participated in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of atrial fibrillation lasting more than 30 seconds in the week after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Atrial fibrillation load;Duration of postoperative ventilator assistance (h) Duration of ICU stay (h) Duration of postoperative hospitalization (d);Inflammatory markers: PCT, IL-6, hsCRP.;The use of amiodarone and the frequency of electric reversion during atrial fibrillation; | — |
Countries
China
Contacts
Public ContactYin Zongtao
Department of Cardiovascular Surgery General Hospital of Northern Theater Comman
Outcome results
None listed