Sepsis - induced cardiomyopathy
Conditions
Interventions
Sepsis without shock group and sepsis with shock group.:There are no special intervention measures, and corresponding treatments are provided according to the guidelines.
Classification 1 (Subgroup analysis, according to ejection fraction):Ejection fraction = 50 (EF = 50%) and ejection fraction preserved group (40% = EF < 50%), ejection fraction reduced group (EF < 40%
:There are no special intervention measures, and corresponding treatments are provided according to the guidelines.
Classification 2 (Subgroup analysis, according to sepsis phenotypes):a, ß, ?, d subgroups.:There are no special intervention measures, and corresponding treatments are provided according to the guidel
Sponsors
The Second Hospital of Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: ? Reach the age of 18 years old; ? Sepsis: A definite infectious focus is identified; Organ dysfunction: The Sequential Organ Failure Assessment (SOFA) score is = 2 points, with or without septic shock: Vasoactive drugs are still required to maintain the mean arterial pressure (MAP) = 65 mmHg after sufficient fluid resuscitation; Serum lactate > 2 mmol/L.
Exclusion criteria
Exclusion criteria: ? Acute myocardial dysfunction: such as acute coronary syndrome, unstable arrhythmia (including bundle branch block) and the status after cardiopulmonary resuscitation, etc.; ? Potential heart diseases: such as congenital heart disease, valvular heart disease, etc., a definite history of myocardial infarction, long-term uncontrolled / poorly controlled hypertension, chronic heart failure caused by various reasons; ? Chronic diseases: long-term chronic hypoxic state, chronic anemia, dialysis; ? Acute events: acute bleeding events, the acute onset period of connective tissue diseases; ? After radiotherapy and chemotherapy for tumors, advanced stage of tumors and the terminal state of other chronic diseases; ? Pregnancy state and perinatal period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean arterial pressure;lactate;Types and Maximum Doses of Vasoactive Drugs;Troponin I;NT - proBNP;Left ventricular global longitudinal strain;left ventricular ejection fraction;The APACHE II score;SOFA Scoring;In - hospital mortality rate;28-day mortality rate;Mortality rate within 3 months;Mortality rate within 6 months; | — |
Secondary
| Measure | Time frame |
|---|---|
| etiology;Vital signs (respiration, heart rate, body temperature).;blood routine test(White blood cell count, neutrophil percentage);biochemical tests(aspartate aminotransferase and alanine aminotransferase, total bilirubin, creatinine, urea nitrogen);coagulation function(Prothrombin activity);Infection Markers (Procalcitonin and Interleukin - 6,C - reactive protein);Length of ICU stay;Duration of ventilator use;Whether continuous renal replacement therapy (CRRT) was carried out.; | — |
Countries
china
Contacts
Public Contactcao wen
The Second Hospital of Lanzhou University
Outcome results
None listed