None listed
Conditions
Interventions
Dextrome sedation group:Dexmedetomidine nasal drops of 100µg (50ug per nostril) were given before operation, and surgical treatment was performed after the drug took effect.
Control group:The same amount of normal saline was given before surgery.
Sponsors
Zhongshan Hospital(Xiamen), Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Age: 18-80 years old. ASA grade I - III. Patients undergoing implantation at infusion port under nerve block. Voluntarily participate and sign the informed consent.
Exclusion criteria
Exclusion criteria: Patient rejection. nasopharyngeal infection or tumor. Patients allergic to the experimental drug. Existing or recent medical conditions that may affect the absorption, distribution, metabolism, excretion, or response to the investigational drug. History of heart disease (valvular insufficiency, severe left ventricular dysfunction), abnormal pacemaker or ECG rhythm (bradycardia <50/min, second or third degree atrioventricular block). Long-term use of opioids or use of other analgesic adjuvants. Participated in other clinical trials within a month. Patients with pregnancy, lactation, and liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient's post-operative Iowa Anesthesia Satisfaction Scale (ISAS); | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative VAS scores of patients;Postoperative sleep quality (St. Mary's Hospital Sleep Questionnaire);Associated adverse reactions in patients after administration;Patient's perioperative vital signs; | — |
Countries
China
Contacts
Public ContactJie Tong
Zhongshan Hospital(Xiamen), Fudan University
Outcome results
None listed