Helicobacter pylori infection
Conditions
Interventions
14-day dual therapy group:14-day vonoprazan- amoxicillin dual therapy
10-day dual therapy group:10-day vonoprazan- amoxicillin dual therapy
7-day quadruple therapy group:7-day vonoprazan- amoxicillin- tetracycline- bismuth quadruple therapy
Sponsors
Qilu Hospital of Shandong University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18-70 years old, no gender limitation; 2.Patients with H.pylori infection (13C/14C urea breath test with any positive result); 3.Patients without previous treatment for H. pylori eradication;
Exclusion criteria
Exclusion criteria: 1.Patients with serious underlying diseases, such as liver insufficiency (AST or ALT greater than the upper limit of normal), active hepatitis, renal dysfunction (Cr >= 2.0mg/dL or GFR= 75%); 2.Patients with active gastrointestinal bleeding; 3.Patients with a history of upper gastrointestinal surgery; 4.Patients allergic to treatment drugs; 5.Patients with medication history of bismuth, antibiotics within 4 weeks, or proton pump inhibitor within 2 weeks; 6.Patients who are pregnant or lactating or unwilling to take contraceptive measures during the trial; 7.Patients with other behaviors that may increase the risk of illness, such as alcohol and drug abuse; 8.Patients who are unwilling or incapable to provide informed consents;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| rate of adverse reactions;compliance; | — |
Countries
China
Contacts
Public ContactYanqing Li
Qilu Hospital of Shandong University
Outcome results
None listed