Gynecological disease
Conditions
Interventions
Experimental group:Esketamine is used during induction
Control group:Fentanyl is used during induction
Sponsors
The Third Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Age :18 ~ 60 years 2.ASAI~II 3.BMI:18.5-23.9kg/m2 4.Indications for hysteroscopic surgery 5.Agree and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1.Combined with severe hypertension, cardiovascular and respiratory diseases 2.She has a history of severe hyperthyroidism 3.Have neurological or mental illness 4.A long history of smoking and alcoholism 5.Have taken or are currently taking opioids and non-steroidal anti-inflammatory drugs 48 hours before surgery 6.Allergic to the investigational drugs esketamine or propofol 7. A history of addiction to opioids, esketamine 8.Uterine or cervical duct congenital malformation, cervical duct stenosis severe 9.Intrauterine adhesions make hysteroscopy difficult to perform 10.Patients who are deemed inappropriate by clinicians to participate in clinical trials
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| QOR-40; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ostoperative rehabilitation index;Anesthetic effect;Systolic pressure;Heart rate;Oxygen saturation;Diastolic pressure; | — |
Countries
China
Contacts
Public ContactLuo Chenfang
The Third Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed