lung injury
Conditions
Interventions
Esketamine group:Esketamine 0.5mg/kg was inducted intravenously in the esketamine anesthesia group and 0.15mg/kg/h in the esketamine group during the operation.
Control group:The same volume of normal saline is infused
Sponsors
The First Affiliated Hospital of Henan University
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Age 30-75 years old, male or female; (2) United States College of Anesthesiologists (ASA) Physical Status Grading System Level II-III; (3) Body mass index (BMI) 19~28 kg/m^2; (4) Elective thoracoscopic radical lung cancer resection
Exclusion criteria
Exclusion criteria: (1) History of preoperative use of radiotherapy, chemotherapy, anti-inflammatory drugs, hormonal drugs and thoracic organ surgery; (2) Patients with severe COPD, interstitial lung disease, bullae, or extremely low preoperative lung function (FEV1% 30 mmHg or SPO2 <90% during intraoperative single-lung ventilation (OLV);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oxygenation index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alveolar-arterial partial pressure difference;Respiratory index;Lung dynamic compliance ;TNF-a, IL-6, IL-10 concentrations;Mean arterial pressure;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactFu Chunyan
The First Affiliated Hospital of Henan University
Outcome results
None listed