Disorders Of Consciousness
Conditions
Interventions
Minimally Conscious State:Provide conventional physical therapy such as traditional rehabilitation acupuncture, positioning, range of motion exercises, tilt table training, rehabilitation cycling, res
Unresponsive Wakefulness Syndrome:Provide conventional physical therapy such as traditional rehabilitation acupuncture, positioning, range of motion exercises, tilt table training, rehabilitation cycl
Control group:Provide conventional physical therapy such as traditional rehabilitation acupuncture, positioning, range of motion exercises, tilt table training, rehabilitation cycling, respiratory reh
Sponsors
Binzhou Medical University Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. GCS score between 4 and 8; 2. 28 days post-onset or post-injury; 3. Age >= 18 years; 4. Known etiology of consciousness disorder; 5. No neurological deficits prior to brain injury; 6. Diagnosed with UWS/VS or MCS based on at least two CRS-R assessments during screening; 7. Informed consent obtained from family members.
Exclusion criteria
Exclusion criteria: 1. Pregnancy; 2. Uncontrolled epilepsy, defined as seizures within 4 weeks prior to enrollment; 3. Intracranial metal implants; 4. Pacemaker; 5. Craniotomy under the stimulation site; 6. Use of sedatives or medications considered to interfere with brain stimulation, such as sodium or calcium channel blockers or NMDA receptor antagonists; 7. Concurrent participation in any other therapeutic clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Coma recovery scale-revised; | — |
Secondary
| Measure | Time frame |
|---|---|
| Power Spestrum;Functional Connectivity; | — |
Countries
China
Contacts
Public ContactHongwei Li
Binzhou Medical University Hospital
Outcome results
None listed