Postoperative nausea and vomiting
Conditions
Interventions
Experimental group:Oxalidine was used for induction, articulation and postoperative analgesia.
Control group:The use of sufentanil for anesthesia analgesia induction, anesthesia analgesia connection and anesthesia analgesia.
Sponsors
The First Affiliated Hospital of Nanchang University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.For laparoscopic gynecological surgery under elective general anesthesia, the operation time was less than 2 hours; 2.Patients with high risk of postoperative vomiting were judged (preoperative Apfel score >=3); 3.ASA grade I-III; 4.Age 18-65 years old (including the critical value); 5.Body mass index (BMI) of 18.5~30kg/m^2(including the critical value); 6.The duration of hospitalization is greater than 48 hours; 7.Have reading and writing ability, voluntarily participate and can sign informed consent.
Exclusion criteria
Exclusion criteria: 1.Inability to understand the nature, significance, possible benefits, possible inconvenience, and potential hazards of the trial, or inability to understand the study procedures, nausea, vomiting, and pain related assessment methods; 2.Preoperative inability to communicate due to cognitive dysfunction or language impairment; 3.A history of chronic pain or opioid abuse before surgery; 4.Patients with gastrointestinal or other related diseases that are prone to vomiting before surgery:; 5.A history of drug use and/or alcoholism within the last 3 months, with an average daily consumption of >2 units of alcohol (1 unit =360ml beer with 5% alcohol or 45ml liquor with 40% alcohol or 150ml wine); 6.Patients who could not estimate the pain intensity after surgery or were transferred to ICU; 7.Patients with estimated surgical blood loss of more than 1000 ml or other serious complications during surgery; 8.Clinically significant liver and kidney function abnormalities (ALT and AST > 2 times the upper limit of normal value; BUN and/or Urea > 2 times the upper limit of normal, Cr > 2 times the upper limit of normal; Dialysis within 28 days prior to surgery), or clinically significant coagulation abnormalities (PT or APTT or TT > upper limit of normal), or poorly controlled blood pressure (sitting SBP > 160mmHg or SBP < 90mmHg), or blood oxygen saturation (unoxygenated) < 94%; 9.Those who have contraindications or allergies to experimental drugs (oxelidine, sufentanil, flurbiprofen exate); 10.People with respiratory depression or high risk of respiratory depression (such as sleep apnea syndrome); 11.Craniocerebral injury, possible intracranial hypertension, brain aneurysm, cerebrovascular accident history, or suffering from central nervous system diseases (such as epilepsy); 12.Suffering from mental illness (such as depression) or taking psychotropic drugs for a long time; 13.Have participated in clinical research of other drugs or medical devices in the past 3 months; 14.Those who were judged not to be enrolled by the researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of nausea and vomiting 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| PACU residence time;Ramsay calm score;QoR-15 scale score;Satisfaction of patients and their families with postoperative analgesia;The severity of postoperative nausea and vomiting;The number of times antiemetic and analgesic drugs were used within 48 hours after surgery;Resting NRS-R pain score;NRS-M pain score during exercise;Incidence of postoperative agitation;Postoperative exhaust time;Postoperative hospitalization time; | — |
Countries
China
Contacts
Public ContactShibiao Chen
The First Affiliated Hospital of Nanchang University
Outcome results
None listed