Advanced ovarian cancer
Conditions
Interventions
Intravenous infusion of TXA:Intravenous infusion of TXA
Intramuscular injection of TXA:Intramuscular injection of TXA
Sponsors
Zhejiang Cancer Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. Adult females with a diagnosis of advanced ovarian cancer undergoing cytopenic surgery aged 20-64 years 2. Classified into stages III-IV based on tumor stage 3. ASA Grading II-III 4. The duration of the operation is >2h 5. Patient signs informed consent
Exclusion criteria
Exclusion criteria: 1. Patient refusal 2. Renal dysfunction (serum creatinine >200 mmol/L) or hepatic dysfunction (Child-Turcotte classification >6) 3. Have severe mental illness or mental disorder, history of epilepsy, visual impairment, etc 4. Previous or current bleeding disorder, coagulopathy, or thromboembolic events 5. Venous thrombosis of the lower extremities 6. Anticoagulants or antifibrinolytic drugs used before surgery within the last month 7. Allergy to TXA
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma concentration of tranexamic acid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood loss; | — |
Countries
China
Contacts
Public ContactXu Pingbo
Zhejiang Cancer Hospital
Outcome results
None listed