sepsis
Conditions
Interventions
Gram-negative sepsis group:None
Healthy control group:None
ICU case control group:None
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: Sepsis: For patients with infection or suspected infection in ICU, when SOFA score > 2, sepsis was diagnosed; For patients with non-ICU infection or suspected infection, when two or more SOFA score are positive (1. Systolic blood pressure =65 times /min; 3. Changes in consciousness), sepsis is diagnosed; Blood culture analysis was positive for Gram-negative infection. ICU case control group: Randomly select age- and gender-matched non-sepsis patients (no systemic inflammatory response syndrome symptoms, no known or suspected infection symptoms) admitted to the ICU during the same period as the ICU case control group. Healthy control group: People with age and sex matched for health examination were randomly selected as normal control group.
Exclusion criteria
Exclusion criteria: < 18 years old; Immunodeficiency virus (HIV) infection; Chemotherapy or hormone therapy within 4 weeks; Unable to sign informed consent; The patient was pregnant or lactating.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expression of Hv1 in peripheral blood mononuclear cells (PBMCs); | — |
Secondary
| Measure | Time frame |
|---|---|
| APACHE? score;SOFA score;Bacterial killing;28-day mortality; | — |
Countries
China
Contacts
Public ContactLingbin Sun
Peking University Shenzhen Hospital
Outcome results
None listed