Osteoporosis
Conditions
Interventions
Treatment group 1:Oral alendronate (70 mg) weekly with glucose-lowering agents other than metformin
All participants received daily supplementation of calcium (1000 mg) and vitamin D (at least 400 IU).
Treatment group 2:Oral alendronate (70 mg) weekly with metformin (2 g/d in divided doses).All participants received daily supplementation of calcium (1000 mg) and vitamin D (at least 400 IU).
Treatment group 3:Oral alendronate (70 mg) once weekly. All participants received daily supplementation of 1000 mg calcium and at least 400 international units of vitamin D.
Treatment group 4:Oral metformin only (2 g daily, divided into two doses). All participants received daily supplementation of 1000 mg calcium and at least 400 international units of vitamin D.
Sponsors
The Affiliated Taizhou People's Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
40 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age greater than 40 years;2.BMD t score of<=-2.5 for the lumbar spine, total hip, or femoral neck, or a BMD t score of <=-1.0 for any of these sites, and a history of one or more fragility fractures of the vertebral, hip, proximal humerus, or distal radius;3.Diagnosed with T2DM according to guidelines of the American Diabetes Association (ADA).
Exclusion criteria
Exclusion criteria: 1. There are contraindications for the use of alendronate or metformin; 2. Hereditary bone disease or secondary osteoporosis; 3. A history of malignant tumors or radiation therapy; 4. Severe heart, lung, liver, or kidney disease; 5. Severe mental illness or cognitive impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bone Mineral Density;Fasting Blood Glucose; | — |
Secondary
| Measure | Time frame |
|---|---|
| Homeostasis Model Assessment of Insulin Resistance;C-terminal telopeptide of type I collagen ;Procollagen Type I N-terminal Propeptide; | — |
Countries
China
Contacts
Public ContactHongyang Kong
The Affiliated Taizhou People's Hospital of Nanjing Medical University
Outcome results
None listed